Now a days sartan family of medicine are on tip of the tongue of pharmaceutical professionals in the view of potential nitrosamine impurities issues and challenges to control it.
Here, we will have a brief overview on the -Sartan family of medicine. To get the answers of very common questions about the Sartans i.e. what are sartans? For what it is being used?
What are sartan drugs and usage?
-Sartan is the suffix given to the drugs which belongs to a class of medicine known as Angiotensin II receptor blockers (ARBs). Like; Valsartan, losartan, Irbesartan, Candesartan, Azilsartan etc.
Name of class speaks, these medicines (-sartans) have a mode of action to block the receptors of Angiotensin II
Angiotensin II is a type of peptide/protein hormone, which leads to narrow the blood vessels to control the blood pressure as well as fluid balance in the body. Hence, these are being used to treat high blood pressure and heart failure.
Origin of angiotensin-II is from protein named angiotensinogen, being secrets by liver. Which further undergoes enzymatic reaction (renin: produced in kidney) and forms angiotensin-I. This angiotensin-I further metabolized and get converted in angiotensin-II, when it enters in bloodstream.
In recent years Nitrosamine impurities has become a very hot topic among the pharmaceutical professionals and researchers. Various pharmaceutical regulators are also in action to get overcome and deal with such problem related to health of human beings.
In upcoming article we will see what is this Issue of Nitrosamine impurities in -sartans.
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